Scheda di dettaglio – i prodotti della ricerca
| Dato | Valore |
|---|---|
| Title | Cytotoxic and antimitotic activities in aqueous extracts of eight cyanobacterial strains isolated from the marine sponge Petrosia ficiformis. |
| Abstract | Marine cyanobacteria are photosynthetic prokaryotes of significant ecological interest, living free or in association with Invertebrates. They are also considered as excellent sources of antineoplastic, antibacterial, antiviral and antifungal compounds. In this work, aqueous extracts from eight cyanobacterial strains isolated from the Mediterranean sponge Petrosia ficiformis have been investigated for their bioactive properties. Bioassays with human erythrocytes, Artemia salina nauplii, and Paracentrotus lividus gametes and embryos were performed. Some aqueous extracts exhibited citolytic effect on human erythrocytes and toxic activity against Artemia salina nauplii. Furthermore antimitotic activity was evidenced during sea urchin embryos development and disorganization of blastomeres with altered cell-cell contact was also induced. Some the isolated cyanobacterial strains, belonging to Leptolyngbya and Synechococcus genera with an high citotoxic activity, should be further investigated to better characterize their bioactive molecules. Our data confirm cyanobacteria as an interesting source of novel bioactive compounds with potential applications in pharmaceutics. |
| Source | Toxicon (Oxf.) 57, pp. 889–896 |
| Keywords | cyanobacterialethality testtoxicology |
| Journal | Toxicon (Oxf.) |
| Editor | Pergamon,, Oxford, Regno Unito |
| Year | 2011 |
| Type | Articolo in rivista |
| DOI | 10.1016/j.toxicon.2011.03.006 |
| Authors | Pagliara P., Caroppo C. |
| Text | 6898 2011 10.1016/j.toxicon.2011.03.006 cyanobacteria lethality test toxicology Cytotoxic and antimitotic activities in aqueous extracts of eight cyanobacterial strains isolated from the marine sponge Petrosia ficiformis. Pagliara P., Caroppo C. Universita del Salento, Lecce Marine cyanobacteria are photosynthetic prokaryotes of significant ecological interest, living free or in association with Invertebrates. They are also considered as excellent sources of antineoplastic, antibacterial, antiviral and antifungal compounds. In this work, aqueous extracts from eight cyanobacterial strains isolated from the Mediterranean sponge Petrosia ficiformis have been investigated for their bioactive properties. Bioassays with human erythrocytes, Artemia salina nauplii, and Paracentrotus lividus gametes and embryos were performed. Some aqueous extracts exhibited citolytic effect on human erythrocytes and toxic activity against Artemia salina nauplii. Furthermore antimitotic activity was evidenced during sea urchin embryos development and disorganization of blastomeres with altered cell cell contact was also induced. Some the isolated cyanobacterial strains, belonging to Leptolyngbya and Synechococcus genera with an high citotoxic activity, should be further investigated to better characterize their bioactive molecules. Our data confirm cyanobacteria as an interesting source of novel bioactive compounds with potential applications in pharmaceutics. 57 Pagliara Caroppo Toxicon 2011 Pagliara_Caroppo_Toxicon_2011.pdf Articolo in rivista Pergamon, 0041 0101 Toxicon Oxf. Toxicon Oxf. Toxicon Oxf. Toxicon. Oxf. carmela.caroppo CAROPPO CARMELA TA.P04.002.001 Fascia Costiera e Ambienti di Transizione analisi strutturale e funzionale delle componenti biotiche ed abiotiche degli ecosistemi per lo sviluppo sostenibile delle attivita TA.P04.029.002 Utilizzazione di biomasse e sostanze attive da organismi marini biotecnologie per loo sviluppo di nuovi bio materiali e composti bioattivi |