Scheda di dettaglio – i prodotti della ricerca
| Dato | Valore |
|---|---|
| Title | Effects of carbon nanotube environmental dispersion on an aquatic invertebrate, Hirudo medicinalis |
| Abstract | The recent widespread applications of nanomaterials, because of their properties, opens new scenarios that affect their dispersal in the environment. In particular multiwall carbon nanotubes (MWCNTs), despite their qualities, seem to be harmful for animals and humans. To evaluate possible toxic effects caused by carbon nanotube environmental dispersion, with regard to aquatic compartment, we proposed as experimental model a freshwater invertebrate: Hirudo medicinalis. In the present study we analyse acute and chronic immune responses over a short (1, 3, 6 and 12 hours) and long time (from 1 to 5 weeks) exposure to MWCNTs by optical, electron and immunohistochemical approaches. In the exposed leeches angiogenesis and fibroplasia accompanied by massive cellular migration occur. Immunocytochemical characterization using specific markers shows that in these inflammatory processes the monocyte-macrophages (CD45+, CD68+) are the most involved cells. These immunocompetent cells are characterized by sequence of events starting from the expression of pro-inflammatory cytokines (in particular IL-18), and amyloidogenensis. Our combined experimental approaches, basing on high sensitive inflammatory response can highlight adverse effects of nanomaterials on aquatic organisms and could be useful to assess the MWCNTs impact on aquatic, terrestrial animal and human health. |
| Source | PloS one 10 |
| Keywords | Carbon NanotubesHirudo medicinalis |
| Journal | PloS one |
| Editor | Public Library of Science, San Francisco, CA, Stati Uniti d'America |
| Year | 2015 |
| Type | Articolo in rivista |
| DOI | 10.1371/journal.pone.0144361 |
| Authors | Girardello R.; Tasselli S.; Baranzini N.; Valvassori R.; De Eguileor M.; Grimaldi A. |
| Text | 453440 2015 10.1371/journal.pone.0144361 Scopus 2 s2.0 84955560894 Carbon Nanotubes Hirudo medicinalis Effects of carbon nanotube environmental dispersion on an aquatic invertebrate, Hirudo medicinalis Girardello R.; Tasselli S.; Baranzini N.; Valvassori R.; De Eguileor M.; Grimaldi A. Department of Biotechnology and Life Sciences, University of Insubria, Varese, , Italy The recent widespread applications of nanomaterials, because of their properties, opens new scenarios that affect their dispersal in the environment. In particular multiwall carbon nanotubes MWCNTs , despite their qualities, seem to be harmful for animals and humans. To evaluate possible toxic effects caused by carbon nanotube environmental dispersion, with regard to aquatic compartment, we proposed as experimental model a freshwater invertebrate Hirudo medicinalis. In the present study we analyse acute and chronic immune responses over a short 1, 3, 6 and 12 hours and long time from 1 to 5 weeks exposure to MWCNTs by optical, electron and immunohistochemical approaches. In the exposed leeches angiogenesis and fibroplasia accompanied by massive cellular migration occur. Immunocytochemical characterization using specific markers shows that in these inflammatory processes the monocyte macrophages CD45 , CD68 are the most involved cells. These immunocompetent cells are characterized by sequence of events starting from the expression of pro inflammatory cytokines in particular IL 18 , and amyloidogenensis. Our combined experimental approaches, basing on high sensitive inflammatory response can highlight adverse effects of nanomaterials on aquatic organisms and could be useful to assess the MWCNTs impact on aquatic, terrestrial animal and human health. 10 Published version http //www.scopus.com/record/display.url eid=2 s2.0 84955560894 origin=inward Articolo in rivista Public Library of Science 1932 6203 PloS one PloS one PLoS ONE PloS one Public Library of Science one PLoS 1 stefanotasselli TASSELLI STEFANO |