| Title | Gold-Speckled SPION@SiO2 Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications |
| Abstract | Efforts are made to perform an early and accurate detection of hepatocellular carcinoma (HCC) by simultaneous exploiting multiple clinically non-invasive imaging modalities. Original nanostructures derived from the combination of different inorganic domains can be used as efficient contrast agents in multimodal imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) and Au nanoparticles (NPs) possess well-established contrasting features in magnetic resonance imaging (MRI) and X-ray computed tomography (CT), respectively. HCC can be targeted by using specific carbohydrates able to recognize asialoglycoprotein receptor 1 (ASGPR1) overexpressed in hepatocytes. Here, two different thiocarbohydrate ligands were purposely designed and alternatively conjugated to the surface of Au-speckled silica-coated SPIONs NPs, to achieve two original nanostructures that could be potentially used for dual mode targeted imaging of HCC. The results indicated that the two thiocarbohydrate decorated nanostructures possess convenient plasmonic/superparamagnetic properties, well-controlled size and morphology and good selectivity for targeting ASGPR1 receptor. |
| Source | Chemistry (Weinh., Print) |
| Keywords | ASGPR1 receptorbioconjugatesgold/silica nanoparticlesSPIONsthiocarbohydrate ligands |
| Journal | Chemistry (Weinh., Print) |
| Editor | Wiley-VCH., Weinheim, Germania |
| Year | 2020 |
| Type | Articolo in rivista |
| DOI | 10.1002/chem.202002142 |
| Authors | Siciliano, Giulia; Corricelli, Michela; Iacobazzi, Rosa Maria; Canepa, Fabio; Comegna, Daniela; Fanizza, Elisabetta; Del Gatto, Annarita; Saviano, Michele; Laquintana, Valentino; Comparelli, Roberto; Mascolo, Giuseppe; Murgolo, Sapia; Striccoli, Marinella; Agostiano, Angela; Denora, Nunzio; Zaccaro, Laura; Curri, M. Lucia; Depalo, Nicoletta |
| Text | 427912 2020 10.1002/chem.202002142 Scopus 2 s2.0 85088785639 ASGPR1 receptor bioconjugates gold/silica nanoparticles SPIONs thiocarbohydrate ligands Gold Speckled SPION@SiO2 Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting Towards HCC Dual Mode Imaging Potential Applications Siciliano, Giulia; Corricelli, Michela; Iacobazzi, Rosa Maria; Canepa, Fabio; Comegna, Daniela; Fanizza, Elisabetta; Del Gatto, Annarita; Saviano, Michele; Laquintana, Valentino; Comparelli, Roberto; Mascolo, Giuseppe; Murgolo, Sapia; Striccoli, Marinella; Agostiano, Angela; Denora, Nunzio; Zaccaro, Laura; Curri, M. Lucia; Depalo, Nicoletta Istituto di Ricerca Sulle Acque, Bari; Istituto di Ricerca sulle Acque, Italy; IRCCS Istituto Tumori Giovanni Paolo II; Universita degli Studi di Genova; Universita del Salento; Universita degli Studi di Bari; Istituto di Cristallografia; Istituto di Biostrutture e Bioimmagini Efforts are made to perform an early and accurate detection of hepatocellular carcinoma HCC by simultaneous exploiting multiple clinically non invasive imaging modalities. Original nanostructures derived from the combination of different inorganic domains can be used as efficient contrast agents in multimodal imaging. Superparamagnetic iron oxide nanoparticles SPIONs and Au nanoparticles NPs possess well established contrasting features in magnetic resonance imaging MRI and X ray computed tomography CT , respectively. HCC can be targeted by using specific carbohydrates able to recognize asialoglycoprotein receptor 1 ASGPR1 overexpressed in hepatocytes. Here, two different thiocarbohydrate ligands were purposely designed and alternatively conjugated to the surface of Au speckled silica coated SPIONs NPs, to achieve two original nanostructures that could be potentially used for dual mode targeted imaging of HCC. The results indicated that the two thiocarbohydrate decorated nanostructures possess convenient plasmonic/superparamagnetic properties, well controlled size and morphology and good selectivity for targeting ASGPR1 receptor. Published version http //www.scopus.com/record/display.url eid=2 s2.0 85088785639 origin=inward Articolo in rivista Wiley VCH. 0947 6539 Chemistry Weinh., Print Chemistry Weinh., Print Chemistry Weinh., Print COMEGNA DANIELA sapia.murgolo MURGOLO SAPIA fabiomichelecanepa CANEPA FABIO MICHELE marialucia.curri CURRI MARIA LUCIA laura.zaccaro ZACCARO LAURA marinella.striccoli STRICCOLI MARINELLA roberto.comparelli COMPARELLI ROBERTO annarita.delgatto DEL GATTO ANNARITA michele.saviano SAVIANO MICHELE giuseppe.mascolo MASCOLO GIUSEPPE |
