Scheda di dettaglio – i prodotti della ricerca
| Dato | Valore |
|---|---|
| Title | DEGRADATION OF THE ANTIVIRAL DRUG OSELTAMIVIR CARBOXYLATE IN SURFACE WATER SAMPLES |
| Abstract | Numerous studies have documented that a wide number of pharmaceuticals used in human and veterinary medicine have the potential to enter the aquatic ecosystem. The antiviral prodrug oseltamivir phosphate has received recent attention with regard to its possible use against the highly pathogenic H5N1 virus. This preliminary laboratory study investigated the persistence of the active antiviral drug, oseltamivir carboxylate (OSC), in water samples taken from an irrigation canal. After an initial rapid decrease, OSC concentrations slowly decreased during the remaining incubation period. Approximately 65% of the initial OSC amount remained in water at the end of the 36-day incubation period. A small amount of OSC was lost both from sterilized water and from sterilized water/sediment samples, suggesting a significant role for microbial degradation. Stimulating microbial processes by the addition of sediments resulted in reduced OSC persistence. Presence of OSC (1.5 mgmL1) did not significantly affect the metabolic potential of the water microbial population, estimated by glyphosate and metolachlor mineralization. In contrast, OSC caused an initial transient decrease in the size of the indigenous microbial population of water samples. |
| Source | International journal of environmental analytical chemistry 87 (8), pp. 579–587 |
| Keywords | TamifluPharmaceuticalsBird fluEnvironmental fateSurface water |
| Journal | International journal of environmental analytical chemistry |
| Editor | Gordon and Breach., New York,, Stati Uniti d'America |
| Year | 2007 |
| Type | Articolo in rivista |
| DOI | 10.1080/03067310601151894 |
| Authors | ACCINELLI C. (1); BARRA CARACCIOLO A. (2); GRENNI P. (2) |
| Text | 42142 2007 10.1080/03067310601151894 ISI Web of Science WOS 000246951200004 Tamiflu Pharmaceuticals Bird flu Environmental fate Surface water DEGRADATION OF THE ANTIVIRAL DRUG OSELTAMIVIR CARBOXYLATE IN SURFACE WATER SAMPLES ACCINELLI C. 1 ; BARRA CARACCIOLO A. 2 ; GRENNI P. 2 1 Department of Agro Environmental Science and Technology, University of Bologna, Viale Fanin 44, 40127 Bologna, Italy; 2 Water Research Institute, National Research Council, Via Reno 1, 00198 Rome, Italy Numerous studies have documented that a wide number of pharmaceuticals used in human and veterinary medicine have the potential to enter the aquatic ecosystem. The antiviral prodrug oseltamivir phosphate has received recent attention with regard to its possible use against the highly pathogenic H5N1 virus. This preliminary laboratory study investigated the persistence of the active antiviral drug, oseltamivir carboxylate OSC , in water samples taken from an irrigation canal. After an initial rapid decrease, OSC concentrations slowly decreased during the remaining incubation period. Approximately 65% of the initial OSC amount remained in water at the end of the 36 day incubation period. A small amount of OSC was lost both from sterilized water and from sterilized water/sediment samples, suggesting a significant role for microbial degradation. Stimulating microbial processes by the addition of sediments resulted in reduced OSC persistence. Presence of OSC 1.5 mgmL1 did not significantly affect the metabolic potential of the water microbial population, estimated by glyphosate and metolachlor mineralization. In contrast, OSC caused an initial transient decrease in the size of the indigenous microbial population of water samples. 87 http //www.tandfonline.com/doi/pdf/10.1080/03067310601151894 Articolo pubblicato Accinelli_et_al_2007_Int_J_Environ_Anal_Chem_87_579_5871.pdf Articolo in rivista Gordon and Breach. 0306 7319 International journal of environmental analytical chemistry. International journal of environmental analytical chemistry International journal of environmental analytical chemistry Int. j. environ. anal. chem. paola.grenni GRENNI PAOLA anna.barracaracciolo BARRA CARACCIOLO ANNA TA.P04.005.007 Strumenti di mitigazione dello stress quali quantitativo per i sistemi idrici |