| Title | Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties |
| Abstract | Echinoderms are a renewable resource with an economic value due to their increasing demand as food and/or source of bioactive molecules exerting antitumor, antiviral, anticoagulant, antioxidant, and antimicrobial activities. In this framework, the present study is aimed at investigating the antibacterial, antioxidant, and hemolytic activities in the three Echinoderm species Echinaster sepositus, Arbacia lixula, and Sphaerechinus granularis. The sea star E. sepositus showed lysozyme-like activity (mean diameter of lysis of 13.4 +/- 0.2 mm), an antimicrobial activity against the human emerging pathogens Staphylococcus aureus, Pseudomonas aeruginosa, and Candida famata, and a strong lytic activity (100 +/- 0.05%) towards the human red blood cells. Furthermore A. lixula and E. sepositus had the highest antioxidant activity (1792.75 +/- 233.7 and 1765.65 +/- 484.58 nmolTE/mL, resp.). From toxicological assays, it was shown that E. sepositus was not toxic towards HeLa cells and Vibrio fischeri, encouraging the exploitation of this species in the pharmaceutical field. Therefore, our findings have implications due to the ongoing explosion of antibiotic-resistant infections because of the new opportunistic pathogens and the need to discover antibacterial agents with new modes of action. Also the recorded antioxidant activity taking into account the need to find natural antioxidants useful for human health is intriguing. |
| Source | Evidence-based complementary and alternative medicine (Print) |
| Keywords | Echinodermantibacterial activityantioxidant activityhemolitic activity |
| Journal | Evidence-based complementary and alternative medicine (Print) |
| Editor | Oxford University Press,, Oxford, Regno Unito |
| Year | 2018 |
| Type | Articolo in rivista |
| DOI | 10.1155/2018/7891748 |
| Authors | Stabili, Loredana; Acquaviva, Maria Immacolata; Cavallo, Rosa Anna; Gerardi, Carmela; Narracci, Marcella; Pagliara, Patrizia |
| Text | 395203 2018 10.1155/2018/7891748 ISI Web of Science WOS 000427183000001 Echinoderm antibacterial activity antioxidant activity hemolitic activity Screening of Three Echinoderm Species as New Opportunity for Drug Discovery Their Bioactivities and Antimicrobial Properties Stabili, Loredana; Acquaviva, Maria Immacolata; Cavallo, Rosa Anna; Gerardi, Carmela; Narracci, Marcella; Pagliara, Patrizia Dipartimento di scienze e Tecnologie Biologiche ed Ambientali, Universita del Salento; Istituto per l Ambiente Marino Costiero, UOS di Taranto, CNR Istituto di Scienze delle Produzioni Alimentari, UOS di Lecce, CNR Echinoderms are a renewable resource with an economic value due to their increasing demand as food and/or source of bioactive molecules exerting antitumor, antiviral, anticoagulant, antioxidant, and antimicrobial activities. In this framework, the present study is aimed at investigating the antibacterial, antioxidant, and hemolytic activities in the three Echinoderm species Echinaster sepositus, Arbacia lixula, and Sphaerechinus granularis. The sea star E. sepositus showed lysozyme like activity mean diameter of lysis of 13.4 / 0.2 mm , an antimicrobial activity against the human emerging pathogens Staphylococcus aureus, Pseudomonas aeruginosa, and Candida famata, and a strong lytic activity 100 / 0.05% towards the human red blood cells. Furthermore A. lixula and E. sepositus had the highest antioxidant activity 1792.75 / 233.7 and 1765.65 / 484.58 nmolTE/mL, resp. . From toxicological assays, it was shown that E. sepositus was not toxic towards HeLa cells and Vibrio fischeri, encouraging the exploitation of this species in the pharmaceutical field. Therefore, our findings have implications due to the ongoing explosion of antibiotic resistant infections because of the new opportunistic pathogens and the need to discover antibacterial agents with new modes of action. Also the recorded antioxidant activity taking into account the need to find natural antioxidants useful for human health is intriguing. Published version Screening of three echinoderm species as new opportunity for drug discovery their bioactivities and antimicrobial properties. evidenced based 2018.pdf Articolo in rivista Oxford University Press, 1741 427X Evidence based complementary and alternative medicine Print Evidence based complementary and alternative medicine Print Evidence based complementary and alternative medicine. Print eCAM Print loredana.stabili STABILI LOREDANA carmela.gerardi GERARDI CARMELA mariaimmacolata.acquaviva ACQUAVIVA MARIA IMMACOLATA marcella.narracci NARRACCI MARCELLA rosaanna.cavallo CAVALLO ROSA ANNA DTA.AD005.084.002 Utilizzazione di biomasse e sostanze attive da organismi marini |
