| Title | Effect-based and chemical analytical methods to monitor estrogens under the European Water Framework Directive |
| Abstract | The European Decision EU 2015/495 included three steroidal estrogens, estrone, 17 beta-estradiol and 17 alpha-ethinyl estradiol, in the "watch-list" of the Water Framework Directive (WFD). As consequence, these substances have to be chemically monitored at the level of their environmental quality standards, which can be challenging. This project aimed to identify reliable effect-based methods (EBMs) for screening of endocrine disrupting compounds, to harmonise monitoring and data interpretation methods, and to contribute to the current WFD review process. Water and wastewater samples were collected across Europe and analysed using chemical analyses and EBMs. The results showed that 17 beta-estradiol equivalents were comparable among methods, while results can vary between methods based on the relative potencies for individual substances. Further, derived 17 beta-estradiol equivalents were highly correlated with LC-MS/MS analyses. This study shows that the inclusion of effect-based screening methods into monitoring programmes for estrogens in surface waterbodies would be a valuable complement to chemical analysis. (C) 2018 Elsevier B.V. All rights reserved. |
| Source | TrAC. Trends in analytical chemistry (Regul. ed.) 102, pp. 225–235 |
| Keywords | Science-policy interfaceEstrogen screeningEndocrine disruptionSurface and waste water assessmentEmerging pollutantsEU watch-listSteroid analysesIn vitro bioassaysIntegrated effects of mixtures |
| Journal | TrAC. Trends in analytical chemistry (Regul. ed.) |
| Editor | Elsevier, Amsterdam, Paesi Bassi |
| Year | 2018 |
| Type | Articolo in rivista |
| DOI | 10.1016/j.trac.2018.02.008 |
| Authors | Koenemann, Sarah; Kase, Robert; Simon, Eszter; Swart, Kees; Buchinger, Sebastian; Schluesener, Michael; Hollert, Henner; Escher, Beate I.; Werner, Inge; Ait-Aissa, Selim; Vermeirssen, Etienne; Dulio, Valeria; Valsecchi, Sara; Polesello, Stefano; Behnisch, Peter; Javurkova, Barbora; Perceval, Olivier; Di Paolo, Carolina; Olbrich, Daniel; Sychrova, Eliska; Schlichting, Rita; Leborgne, Lomig; Clara, Manfred; Scheffknecht, Christoph; Marneffe, Yves; Chalon, Carole; Tusil, Petr; Soldan, Premysl; von Danwitz, Brigitte; Schwaiger, Julia; San Martin Becares, Maria Isabel; Bersani, Francesca; Hilscherova, Klara; Reifferscheid, Georg; Ternes, Thomas; Carere, Mario |
| Text | 390540 2018 10.1016/j.trac.2018.02.008 ISI Web of Science WOS 000435751100016 Scopus 2 s2.0 85045795829 Science policy interface Estrogen screening Endocrine disruption Surface and waste water assessment Emerging pollutants EU watch list Steroid analyses In vitro bioassays Integrated effects of mixtures Effect based and chemical analytical methods to monitor estrogens under the European Water Framework Directive Koenemann, Sarah; Kase, Robert; Simon, Eszter; Swart, Kees; Buchinger, Sebastian; Schluesener, Michael; Hollert, Henner; Escher, Beate I.; Werner, Inge; Ait Aissa, Selim; Vermeirssen, Etienne; Dulio, Valeria; Valsecchi, Sara; Polesello, Stefano; Behnisch, Peter; Javurkova, Barbora; Perceval, Olivier; Di Paolo, Carolina; Olbrich, Daniel; Sychrova, Eliska; Schlichting, Rita; Leborgne, Lomig; Clara, Manfred; Scheffknecht, Christoph; Marneffe, Yves; Chalon, Carole; Tusil, Petr; Soldan, Premysl; von Danwitz, Brigitte; Schwaiger, Julia; San Martin Becares, Maria Isabel; Bersani, Francesca; Hilscherova, Klara; Reifferscheid, Georg; Ternes, Thomas; Carere, Mario Rhein Westfal TH Aachen; Eawag EPFL; BioDetect Syst Bv; Bundesanstalt Gewasserkunde; UFZ Helmholtz Ctr Environm Res; Eberhard Karls Univ Tubingen; INERIS; Ist Ric Acque; Masaryk Univ; French Natl Agcy Water Aquat Environm; Agence Eau Adour Garonne; Umweltbundesamt; Inst Umwelt Lebensmittelsicherheit Landes Vorar; Inst Sci Serv Publ ISSeP; TG Masaryk Water Res Inst; Landesamt Nat Umwelt Verbraucherschutz NRW LANU; Bayer Landesamt Umwelt; Univ Leon; Soc Metropolitana Acque Torino SpAC; Natl Inst Hlth The European Decision EU 2015/495 included three steroidal estrogens, estrone, 17 beta estradiol and 17 alpha ethinyl estradiol, in the watch list of the Water Framework Directive WFD . As consequence, these substances have to be chemically monitored at the level of their environmental quality standards, which can be challenging. This project aimed to identify reliable effect based methods EBMs for screening of endocrine disrupting compounds, to harmonise monitoring and data interpretation methods, and to contribute to the current WFD review process. Water and wastewater samples were collected across Europe and analysed using chemical analyses and EBMs. The results showed that 17 beta estradiol equivalents were comparable among methods, while results can vary between methods based on the relative potencies for individual substances. Further, derived 17 beta estradiol equivalents were highly correlated with LC MS/MS analyses. This study shows that the inclusion of effect based screening methods into monitoring programmes for estrogens in surface waterbodies would be a valuable complement to chemical analysis. C 2018 Elsevier B.V. All rights reserved. 102 Published version articolo 2018_Koneman_TRAC_EDC2.pdf Articolo in rivista Elsevier 0165 9936 TrAC. Trends in analytical chemistry Regul. ed. TrAC. Trends in analytical chemistry Regul. ed. TrAC, Trends anal. chem. Regul. ed. Trends in analytical chemistry Personal edition Regul. ed. stefano.polesello POLESELLO STEFANO saramaria.valsecchi VALSECCHI SARA MARIA |
