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DatoValore
TitleAssessment of gemfibrozil persistence in river water alone and in co-presence of naproxen
AbstractGemfibrozil is a pharmaceutical commonly found in the aquatic compartment and its presence together with a mixture of several other biologically-active drugs raises concern about the possible long-term adverse effects on biota chronically exposed. Most research focus on its effect/degradation in wastewater treatment plant, while few investigations take into account its persistence in receiving aquatic ecosystems and its effects on natural microbial communities. In this context, the present work aims to evaluate gemfibrozil biodegradation, alone or in the co-presence of naproxen, comparing its persistence in the presence/absence of the river natural microbial community. For this purpose, water samples were collected from a river Tiber stretch inside the city of Rome and located downstream from a wastewater treatment plant and used for degradation experiments. Microbiologically active or sterile water microcosms were set up and treated with 100 ?g L- 1 of gemfibrozil alone or in the co-presence of naproxen (100 ug L- 1), in order to evaluate gemfibrozil degradation in the different conditions. At fixed times water samplings were collected for both chemical and microbiological analysis. Moreover, the effects of the pharmaceuticals on the microbial community structure in terms of variations in its abundance and composition were also assessed. The overall results showed gemfibrozil to be a quite persistent molecule in the river water microcosms and the natural microbial community had a key role in its biodegradation. The co-presence of naproxen, a non-steroidal anti-inflammatory drug commonly co-occurring with gemfibrozil, increased its persistence and affected negatively some bacterial groups presence.
SourceMicrochemical journal (Print) 136c, pp. 49–55
KeywordsGemfibrozil biodegradationRiver microbial communityMicrocosm studyBacterial phylogenetic composition
JournalMicrochemical journal (Print)
EditorAcademic Press [etc.], New York,, Stati Uniti d'America
Year2018
TypeArticolo in rivista
DOI10.1016/j.microc.2016.11.018
AuthorsGrenni P, Patrolecco L,Ademollo N, Di Lenola M, Barra Caracciolo A
Text366857 2018 10.1016/j.microc.2016.11.018 Scopus 2 s2.0 85007553209 ISI Web of Science WOS WOS 000412958200006 Gemfibrozil biodegradation River microbial community Microcosm study Bacterial phylogenetic composition Assessment of gemfibrozil persistence in river water alone and in co presence of naproxen Grenni P, Patrolecco L,Ademollo N, Di Lenola M, Barra Caracciolo A Water Research Institute, National Research Council, Via Salaria km 29.300, 00015 Monterotondo Scalo, RM, Italy Gemfibrozil is a pharmaceutical commonly found in the aquatic compartment and its presence together with a mixture of several other biologically active drugs raises concern about the possible long term adverse effects on biota chronically exposed. Most research focus on its effect/degradation in wastewater treatment plant, while few investigations take into account its persistence in receiving aquatic ecosystems and its effects on natural microbial communities. In this context, the present work aims to evaluate gemfibrozil biodegradation, alone or in the co presence of naproxen, comparing its persistence in the presence/absence of the river natural microbial community. For this purpose, water samples were collected from a river Tiber stretch inside the city of Rome and located downstream from a wastewater treatment plant and used for degradation experiments. Microbiologically active or sterile water microcosms were set up and treated with 100 g L 1 of gemfibrozil alone or in the co presence of naproxen 100 ug L 1 , in order to evaluate gemfibrozil degradation in the different conditions. At fixed times water samplings were collected for both chemical and microbiological analysis. Moreover, the effects of the pharmaceuticals on the microbial community structure in terms of variations in its abundance and composition were also assessed. The overall results showed gemfibrozil to be a quite persistent molecule in the river water microcosms and the natural microbial community had a key role in its biodegradation. The co presence of naproxen, a non steroidal anti inflammatory drug commonly co occurring with gemfibrozil, increased its persistence and affected negatively some bacterial groups presence. 136c Published version http //www.scopus.com/record/display.url eid=2 s2.0 85007553209 origin=inward 26/11/2016 ARTICOLO PUBBLICATO ARTICOLO PUBBLICATO Nap_Gem_MicrochemJ.pdf Articolo in rivista Academic Press etc. 0026 265X Microchemical journal Print Microchemical journal Print Microchemical journal. Print DI LENOLA MARTINA luisa.patrolecco PATROLECCO LUISA anna.barracaracciolo BARRA CARACCIOLO ANNA paola.grenni GRENNI PAOLA nicoletta.ademollo ADEMOLLO NICOLETTA TA.P04.005.011 Vulnerabilita degli ecosistemi delle acque sotterranee e attenuazione naturale degli inquinanti nel suolo e nel sottosuolo