Scheda di dettaglio – i prodotti della ricerca
| Dato | Valore |
|---|---|
| Title | Toxicity and genotoxicity of surface water before and after various potabilization steps |
| Abstract | Many studies have revealed the presence of compounds with genotoxic activity in drinking water by means of short-term mutagenicity tests. In this study, the influence of the different steps of surface water treatment on the mutagenicity of drinking water was evaluated. Four different types of samples were collected: raw lake water, water after pre-disinfection with chlorine dioxide, water after filtration on granular activated carbon, and tap water. Water extracts underwent a bacterial toxicity test (Microtox test) and different in vitro genotoxicity tests: a test with Salmonella typhimurium strains, a Saccharomyces cerevisiae test, the SOS Chromotest with Escherichia coli and the Mutatox test with Vibrio fischeri. The Microtox test revealed high toxicity in the treated water samples. The disinfection steps increased the toxicity: the Mutatox test confirmed these results and the Salmonella/microsome test at the highest doses showed toxicity that could conceal mutagenicity. The SOS Chromotest was positive in all treated water samples without metabolic activation. In the test with S. cerevisiae both toxicity and genotoxicity generally increased during the water treatment steps, especially in cells without induction of cytochrome P450. © 2005 Elsevier B.V. All rights reserved. |
| Source | Mutation research. Genetic toxicology and environmental mutagenesis (Print) 587 (1-2), pp. 26–37 |
| Keywords | DisinfectionDrinking waterMutagenicityToxicityTreatment plant |
| Journal | Mutation research. Genetic toxicology and environmental mutagenesis (Print) |
| Editor | Elsevier, Tokyo ;, Paesi Bassi |
| Year | 2005 |
| Type | Articolo in rivista |
| DOI | 10.1016/j.mrgentox.2005.07.006 |
| Authors | Zani, Claudia; Feretti, Donatella; Buschini, Annamaria; Poli, Paola; Rossi, Carlo; Guzzella, Licia; Di Caterino, Filomena; Monarca, Silvano |
| Text | 339348 2005 10.1016/j.mrgentox.2005.07.006 Scopus 2 s2.0 27144503642 Disinfection Drinking water Mutagenicity Toxicity Treatment plant Toxicity and genotoxicity of surface water before and after various potabilization steps Zani, Claudia; Feretti, Donatella; Buschini, Annamaria; Poli, Paola; Rossi, Carlo; Guzzella, Licia; Di Caterino, Filomena; Monarca, Silvano Universita degli Studi di Brescia; Universita degli Studi di Parma; Consiglio Nazionale delle Ricerche; Universita degli Studi di Perugia Many studies have revealed the presence of compounds with genotoxic activity in drinking water by means of short term mutagenicity tests. In this study, the influence of the different steps of surface water treatment on the mutagenicity of drinking water was evaluated. Four different types of samples were collected raw lake water, water after pre disinfection with chlorine dioxide, water after filtration on granular activated carbon, and tap water. Water extracts underwent a bacterial toxicity test Microtox test and different in vitro genotoxicity tests a test with Salmonella typhimurium strains, a Saccharomyces cerevisiae test, the SOS Chromotest with Escherichia coli and the Mutatox test with Vibrio fischeri. The Microtox test revealed high toxicity in the treated water samples. The disinfection steps increased the toxicity the Mutatox test confirmed these results and the Salmonella/microsome test at the highest doses showed toxicity that could conceal mutagenicity. The SOS Chromotest was positive in all treated water samples without metabolic activation. In the test with S. cerevisiae both toxicity and genotoxicity generally increased during the water treatment steps, especially in cells without induction of cytochrome P450. © 2005 Elsevier B.V. All rights reserved. 587 Published version http //www.scopus.com/record/display.url eid=2 s2.0 27144503642 origin=inward Articolo in rivista Elsevier 1383 5718 Mutation research. Genetic toxicology and environmental mutagenesis Print Mutation research. Genetic toxicology and environmental mutagenesis Print Mutat. res., Genet. toxicol. environ. mutagen. Print Mutation research. Print liciamaria.guzzella GUZZELLA LICIA MARIA |