Scheda di dettaglio – i prodotti della ricerca
| Dato | Valore |
|---|---|
| Title | An on-line solid phase extraction-liquid chromatography-tandem mass spectrometry method for the determination of perfluoroalkyl acids in drinking and surface waters |
| Abstract | An UHPLC-MS/MS multiresidue method based on an on-line solid phase extraction (SPE) procedure was developed for the simultaneous determination of 9 perfluorinated carboxylates (from 4 to 12 carbon atoms) and 3 perfluorinated sulphonates (from 4 to 8 carbon atoms). This work proposes using an on-line solid phase extraction before chromatographic separation and analysis to replace traditional methods of off-line SPE before direct injection to LC-MS/MS. Manual sample preparation was reduced to sample centrifugation and acidification, thus eliminating several procedural errors and significantly reducing time-consuming and costs. Ionization suppression between target perfluorinated analytes and their coeluting SIL-IS were detected for homologues with a number of carbon atoms less than 9, but the quantitation was not affected. Total matrix effect corrected by SIL-IS, inclusive of extraction efficacy, and of ionization efficiency, ranged between -34 and +39%. The percentage of recoveries, between 76 and 134%, calculated in different matrices (tap water and rivers impacted by different pollutions) was generally satisfactory. LODs and LOQs of this on-line SPE method, which also incorporate recovery losses, ranged from 0.2 to 5.0 ng/L and from 1 to 20 ng/L, respectively. Validated on-line SPE-LC/MS/MS method has been applied in a wide survey for the determination of perfluoroalkyl acids in Italian surface and ground waters. |
| Source | Journal of Analytical Methods in Chemistry 2015, pp. 1–13 |
| Keywords | on-line SPEPFASLC-MS |
| Journal | Journal of Analytical Methods in Chemistry |
| Editor | Hindawi Publishing Corporation, , |
| Year | 2015 |
| Type | Articolo in rivista |
| DOI | 10.1155/2015/942016 |
| Authors | Mazzoni M.; Rusconi M.; Valsecchi S.; Martins C.P.B.; Polesello S. |
| Text | 335308 2015 10.1155/2015/942016 Scopus 2 s2.0 84925307965 on line SPE PFAS LC MS An on line solid phase extraction liquid chromatography tandem mass spectrometry method for the determination of perfluoroalkyl acids in drinking and surface waters Mazzoni M.; Rusconi M.; Valsecchi S.; Martins C.P.B.; Polesello S. IRSA CNR, Water Research Institute, Via Mulino 19, Brugherio, 20861, Italy; Thermo Fisher Scientific, 16 avenue du Quebec, Silic 765, Villebon sur Yvette Courtaboeuf Cedex, 91963, France An UHPLC MS/MS multiresidue method based on an on line solid phase extraction SPE procedure was developed for the simultaneous determination of 9 perfluorinated carboxylates from 4 to 12 carbon atoms and 3 perfluorinated sulphonates from 4 to 8 carbon atoms . This work proposes using an on line solid phase extraction before chromatographic separation and analysis to replace traditional methods of off line SPE before direct injection to LC MS/MS. Manual sample preparation was reduced to sample centrifugation and acidification, thus eliminating several procedural errors and significantly reducing time consuming and costs. Ionization suppression between target perfluorinated analytes and their coeluting SIL IS were detected for homologues with a number of carbon atoms less than 9, but the quantitation was not affected. Total matrix effect corrected by SIL IS, inclusive of extraction efficacy, and of ionization efficiency, ranged between 34 and 39%. The percentage of recoveries, between 76 and 134%, calculated in different matrices tap water and rivers impacted by different pollutions was generally satisfactory. LODs and LOQs of this on line SPE method, which also incorporate recovery losses, ranged from 0.2 to 5.0 ng/L and from 1 to 20 ng/L, respectively. Validated on line SPE LC/MS/MS method has been applied in a wide survey for the determination of perfluoroalkyl acids in Italian surface and ground waters. 2015 Published version http //www.scopus.com/inward/record.url eid=2 s2.0 84925307965 partnerID=q2rCbXpz paper 2015_Mazzoni_JAMC_onlinePFAS.pdf Articolo in rivista Hindawi Publishing Corporation 2090 8873 Journal of Analytical Methods in Chemistry Journal of Analytical Methods in Chemistry mariannarusconi RUSCONI MARIANNA MAZZONI MICHELA stefano.polesello POLESELLO STEFANO saramaria.valsecchi VALSECCHI SARA MARIA |