| Title | Epidemiological and clinical characteristics of pediatric gastroenteritis associated with new viral agents |
| Abstract | A 22-month study (2008-2009) was carried out on 273 patients (average age 40 months), admitted with gastroenteritis to the Pediatric Unit of L. Sacco University Hospital in Milan, Italy. Fecal samples were investigated for rotavirus (HRV), norovirus (NoV), adenovirus (AdV), sapovirus (SaV), enterovirus, astrovirus and bocavirus (HBoV). A 38.3% incidence of infection was observed for HRV, followed by NoV (16.2%), HBoV (13.6%), AdV (2.6%) and SaV (0.6%). Clinical evaluation of 109 gastroenteritis patients with confirmed diagnosis was graded by the Ruska-Vesikari scoring system, showing vomiting (78%), diarrhea (96%) and fever (80%). A total of 25 NoV-positive samples were selected for nucleotide sequence analysis. The severity of AdV-associated infection was lower than for NoV, HRV and HBoV. These latter viruses caused similar symptoms that were indistinguishable using clinical information. NoV, HRV and HBoV were often present as mixed infections (13.1%). Sequencing of NoV-positive samples allowed identification of GII.2, GII.3 and GII.4 2006 variants. |
| Source | Archives of virology 156 (9), pp. 1583–1589 |
| Journal | Archives of virology |
| Editor | Springer, New York, Austria |
| Year | 2011 |
| Type | Articolo in rivista |
| DOI | 10.1007/s00705-011-1037-5 |
| Authors | Rimoldi, Sara Giordana; Stefani, Fabrizio; Pagani, Cristina; Chenal, Lisa Lucia; Zanchetta, Nadia; Di Bartolo, Ilaria; Lombardi, Alessandra; Ruggeri, Franco Maria; Di Iillo, Dario; Zuccotti, Gian Vincenzo; Gismondo, Maria Rita |
| Text | 307768 2011 10.1007/s00705 011 1037 5 ISI Web of Science WOS 000294461800011 Epidemiological and clinical characteristics of pediatric gastroenteritis associated with new viral agents Rimoldi, Sara Giordana; Stefani, Fabrizio; Pagani, Cristina; Chenal, Lisa Lucia; Zanchetta, Nadia; Di Bartolo, Ilaria; Lombardi, Alessandra; Ruggeri, Franco Maria; Di Iillo, Dario; Zuccotti, Gian Vincenzo; Gismondo, Maria Rita L Sacco Hosp Vialba; Univ Hosp L Sacco; University of Milano Bicocca; Istituto Superiore di Sanita ; Univ Hosp L Sacco A 22 month study 2008 2009 was carried out on 273 patients average age 40 months , admitted with gastroenteritis to the Pediatric Unit of L. Sacco University Hospital in Milan, Italy. Fecal samples were investigated for rotavirus HRV , norovirus NoV , adenovirus AdV , sapovirus SaV , enterovirus, astrovirus and bocavirus HBoV . A 38.3% incidence of infection was observed for HRV, followed by NoV 16.2% , HBoV 13.6% , AdV 2.6% and SaV 0.6% . Clinical evaluation of 109 gastroenteritis patients with confirmed diagnosis was graded by the Ruska Vesikari scoring system, showing vomiting 78% , diarrhea 96% and fever 80% . A total of 25 NoV positive samples were selected for nucleotide sequence analysis. The severity of AdV associated infection was lower than for NoV, HRV and HBoV. These latter viruses caused similar symptoms that were indistinguishable using clinical information. NoV, HRV and HBoV were often present as mixed infections 13.1% . Sequencing of NoV positive samples allowed identification of GII.2, GII.3 and GII.4 2006 variants. 156 Articolo in rivista Springer 0304 8608 Archives of virology Archives of virology Arch. virol. Archives of virology. Archives of virology Print fabrizio.stefani STEFANI FABRIZIO |
