Scheda di dettaglio – i prodotti della ricerca
| Dato | Valore |
|---|---|
| Title | Mitochondrial impairment induces excitotoxic death in cerebellar granule cells |
| Abstract | A close relationship links mitochondria to cell death with mitochondrial function-impairment considered a major biochemical event in the process of both apoptosis and necrosis. We have used different inhibitors of oxidative phosphorylation, i.e. mitochondrial respiratory chain and ATP synthesis inhibitors, and an uncoupler to investigate the mode of cell death caused by these compounds in cerebellar granule cells. This study shows that in cultured cerebellar granule cells either oxidative phosphorylation inhibitors or uncoupler induce an excitotoxic-like reaction which is mediated by activation of NMDA receptors and is likely due to the release of glutamate. Consistently, survival may occur if the toxic action of glutamate is prevented. |
| Source | International Journal of Molecular Medicine 13, pp. 873–876 |
| Keywords | cell deathapoptosismitochondriacerebellar granule cells |
| Journal | International Journal of Molecular Medicine |
| Editor | D. A. Spandidos, Athens, Grecia |
| Year | 2004 |
| Type | Articolo in rivista |
| Authors | Bobba A; Atlante A; Azzariti A; Sgaramella G; Calissano P; Marra E |
| Text | 168352 2004 ISI Web of Science WOS 000221440500020 cell death apoptosis mitochondria cerebellar granule cells Mitochondrial impairment induces excitotoxic death in cerebellar granule cells Bobba A; Atlante A; Azzariti A; Sgaramella G; Calissano P; Marra E Istituto di Biomembrane e Bioenergetica, CNR, Via Amendola 165/A, 70126 Bari; Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 15, 00137 Roma, Italy. A close relationship links mitochondria to cell death with mitochondrial function impairment considered a major biochemical event in the process of both apoptosis and necrosis. We have used different inhibitors of oxidative phosphorylation, i.e. mitochondrial respiratory chain and ATP synthesis inhibitors, and an uncoupler to investigate the mode of cell death caused by these compounds in cerebellar granule cells. This study shows that in cultured cerebellar granule cells either oxidative phosphorylation inhibitors or uncoupler induce an excitotoxic like reaction which is mediated by activation of NMDA receptors and is likely due to the release of glutamate. Consistently, survival may occur if the toxic action of glutamate is prevented. 13 Mitochondrial impairment induces excitotoxic death in cerebellar granule cells Int_J_Mol_Med_2004.pdf Articolo in rivista D. A. Spandidos 1107 3756 International Journal of Molecular Medicine International Journal of Molecular Medicine Int. J. Mol. Med. International Journal of Molecular Medicine. pietro.calissano CALISSANO PIETRO anna.atlante ATLANTE ANNA antonella.bobba BOBBA ANTONELLA giuseppe.sgaramella SGARAMELLA GIUSEPPE ersilia.marra MARRA ERSILIA SV.P15.003.001 Interrelazione nucleo/citoplasma/mitocondri nell omeostasi cellulare. |