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DatoValore
TitleInteractions of Anionic Carboranylated Porphyrins with DNA.
AbstractIn this study, the authors have characterized the acid-base equil. of meso-tetrakis[4-(nido-carboranyl)phenyl]porphyrin (p-H2TCP4-) and meso-tetrakis[3-(nido-carboranyl)phenyl]porphyrin (m-H2TCP4-) and investigated their interactions with DNA. The authors present evidence that these tetraanionic mols. do indeed interact with DNA under physiol. conditions (pH 7.4, and ionic strength I = 0.15 M NaCl). Furthermore, the authors show that the counterintuitive binding of these tetraanionic porphyrins to a 2-fold array of neg. charges is driven by mol. recognition processes that can be deeply affected by the spatial distribution of the anionic substituents. The authors have shown that neg. charged porphyrins bearing peripheric bulky nido-carborane groups can indeed interact with DNA. In addn., the authors have shown that the complexation between anionic porphyrins and DNA can be induced by either porphyrin inner core protonation or other noncovalent interactions. A more complete study of these systems is currently underway since a deeper understanding of these processes might lead to the design of new anticancer drugs with improved biol. activity and treatment effectiveness.
SourceJournal of the American Chemical Society (Print) 123, pp. 5835–5836
KeywordsPorfirineDNAsistemi supramolecolaridicroismo circolare
JournalJournal of the American Chemical Society (Print)
EditorAmerican Chemical Society], [Washington, etc.,, Stati Uniti d'America
Year2001
TypeArticolo in rivista
AuthorsLauceri, Rosaria; Purrello, Roberto; Shetty, Shankar J.; Vicente, M. Graca H.
Text13434 2001 Porfirine DNA sistemi supramolecolari dicroismo circolare Interactions of Anionic Carboranylated Porphyrins with DNA. Lauceri, Rosaria; Purrello, Roberto; Shetty, Shankar J.; Vicente, M. Graca H. Istituto per lo Studio delle Sostanze Naturali di Interesse Alimentare e Chimico Farmaceutico Sezione di Catania attualmente Istituto di Biostrutture e Bioimmagini Sezione di Catania ; Dipartimento di Scienze Chimiche Universita di Catania; Departments of Chemistry and Neurological Surgery University of California, Davis, California 95616 In this study, the authors have characterized the acid base equil. of meso tetrakis 4 nido carboranyl phenyl porphyrin p H2TCP4 and meso tetrakis 3 nido carboranyl phenyl porphyrin m H2TCP4 and investigated their interactions with DNA. The authors present evidence that these tetraanionic mols. do indeed interact with DNA under physiol. conditions pH 7.4, and ionic strength I = 0.15 M NaCl . Furthermore, the authors show that the counterintuitive binding of these tetraanionic porphyrins to a 2 fold array of neg. charges is driven by mol. recognition processes that can be deeply affected by the spatial distribution of the anionic substituents. The authors have shown that neg. charged porphyrins bearing peripheric bulky nido carborane groups can indeed interact with DNA. In addn., the authors have shown that the complexation between anionic porphyrins and DNA can be induced by either porphyrin inner core protonation or other noncovalent interactions. A more complete study of these systems is currently underway since a deeper understanding of these processes might lead to the design of new anticancer drugs with improved biol. activity and treatment effectiveness. 123 Interactions of Anionic Carboranylated Porphyrins with DNA Carboranylated1.pdf Articolo in rivista American Chemical Society 0002 7863 Journal of the American Chemical Society Print Journal of the American Chemical Society Print J. Am. Chem. Soc. Print Journal of the American Chemical Society. Print rosaria.lauceri LAUCERI ROSARIA