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TitleXenobiotic-metabolizing enzymes system in test fish. I Comparative studies of liver microsomal momooxygenases
AbstractAll monooxygenase activities assayed in guppy (Poecilia reticulata) and red killifish (0ryzias latipes) were 7-10 times higher than those measured in trout (Salmo gairdneri), carp (Cyprinus carpio), and golden orfe (Leuciscus idusf. Cytochrome P-450 was 3 times higher in the former fish than in all the other species. Zebra fish (Brachydanio rerio) 7-ethoxycoumarin O-deethylase and bluegill (Lepomis macrochirus) ethylmorphine N-demethylase (EMND) were not greatly different from those of the former group. ol-Naphthoflavone (NF) and methyrapone (MET) exerted qualitatively different actions on benzo[a]pyrene hydroxylase ofguppy, trout, and bluegill liver: both chemicals enhanced the bluegill activity and inhibited that of trout; the guppy liver enzyme was inhibited by MET and activated by NF. EMND activity was inhibited by either compound in the three species. The relevance of all these data to the European Economic Community ecotoxicity tests is discussed. 1987 Academic press, IIK
SourceEcotoxicology and environmental safety (Online) 13, pp. 24–31
Keywordsenvironmental chemistryfishdetoxifying properties
JournalEcotoxicology and environmental safety (Online)
EditorAcademic Press, Orlando, Fla., Paesi Bassi
Year1987
TypeArticolo in rivista
AuthorsFUNARI E., ZOPPINI A., DE ANGELIS G., VERDINA A. , VITTOZZI L.
Text240125 1987 environmental chemistry fish detoxifying properties Xenobiotic metabolizing enzymes system in test fish. I Comparative studies of liver microsomal momooxygenases FUNARI E., ZOPPINI A., DE ANGELIS G., VERDINA A. , VITTOZZI L. ISS, Roma All monooxygenase activities assayed in guppy Poecilia reticulata and red killifish 0ryzias latipes were 7 10 times higher than those measured in trout Salmo gairdneri , carp Cyprinus carpio , and golden orfe Leuciscus idusf. Cytochrome P 450 was 3 times higher in the former fish than in all the other species. Zebra fish Brachydanio rerio 7 ethoxycoumarin O deethylase and bluegill Lepomis macrochirus ethylmorphine N demethylase EMND were not greatly different from those of the former group. ol Naphthoflavone NF and methyrapone MET exerted qualitatively different actions on benzo a pyrene hydroxylase ofguppy, trout, and bluegill liver both chemicals enhanced the bluegill activity and inhibited that of trout; the guppy liver enzyme was inhibited by MET and activated by NF. EMND activity was inhibited by either compound in the three species. The relevance of all these data to the European Economic Community ecotoxicity tests is discussed. 1987 Academic press, IIK 13 http //ac.els cdn.com/014765138790039X/1 s2.0 014765138790039X main.pdf _tid=a1366d6e ea37 11e2 a434 00000aab0f02 acdnat=1373553722_de5332ebbb9da1b15d987d50bfde5314 Xenobiotic metabolizing enzymes system in test fish. I Comparative studies of liver microsomal momooxygenases Funari_et_al_1987.pdf Articolo in rivista Academic Press 1090 2414 Ecotoxicology and environmental safety Online Ecotoxicology and environmental safety Online Ecotoxicol. environ. saf. Online Ecotoxicology and environmental safety Online Environmental research. Online Section B Online EES Online annamaria.zoppini ZOPPINI ANNAMARIA